Stem Cells in New Zealand Black Mice Precursors from Pluripotent Hematopoietic Impaired Development of T Lymphoid
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Role of mir-15a/16-1 in early B cell development in a mouse model of chronic lymphocytic leukemia
In both human chronic lymphocytic leukemia (CLL) and the New Zealand Black (NZB) murine model of CLL, decreased levels of microRNAs miR-15a/16 play an important role in the disease. Here we investigate the effects of this microRNA on early steps of B cell development and the capacity of miR-15a-deficient hematopoietic stem cells (HSC) and B1 progenitor cells (B1P) to reproduce CLL-like phenotyp...
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تاریخ انتشار 2001